Process Analytics Products

At-line Analysis for Cell Culture Media

Built on the proven foundation of the award winning PATsmart™ REBEL® analyzer, the PATsmart™ REBEL XT® System continues to challenge the limits of traditional lab testing—delivering the next level of at-line cell culture media analysis with greater reliability, streamlined usability, and tighter analytical performance. Designed for real-world cell culture media process development, it delivers faster, real-time insights into media composition—giving you the data you need, exactly where and when you need it.

Process Analytical Technology for In-line Bioprocess Analysis

This easy-to-use process analytical technology device offers in-line bioprocess analysis and control with no complex modeling. Measure multiple critical parameters across media, across processes, across mammalian cell lines, across scales.

Take command of your cell culture process with the PATsmart™ MAVEN^® Online Glucose and Lactate Monitoring System. Delivering continuous, sample-free glucose data every 2 minutes, MAVEN automates feeding strategies, reduces variability, and frees your team from manual sampling. Built to integrate seamlessly, it brings precision and efficiency to every run—without disrupting your workflow.

Microfluidic CE-MS interface for rapid, high-efficiency separations

The PATsmart™ ZipChip® CE-MS interface uses microfluidic capillary electrophoresis to enable rapid, high-efficiency separations of complex biological samples prior to mass spectrometry. By simplifying sample preparation and streamlining sample introduction to the MS, ZipChip reduces analysis time and improves workflow efficiency for protein characterization and metabolomic applications.

UV-Vis Concentration Measurement for GMP and Non-GMP Testing

The new PATsmart™ SoloVPE^® PLUS System features patented variable pathlength technology (VPT), providing precise concentration measurements with no need for costly dilutions. This reliable solution delivers fast, accurate results with system-to-system, operator-to-operator, and site-to-site consistency, ensuring high-quality performance across various bioprocessing applications.

Continuous in-line concentration measurement for real-time process control

Designed for GMP environments, the PATsmart™ FlowVPX® spectrophotometer delivers continuous, in-line concentration measurement during downstream processing, providing real-time data to actively control the process as it runs. This level of control is made possible by Variable Pathlength Technology (VPT), which enables accurate, dilution-free concentration measurement across development, scale-up, and GMP manufacturing.

In-line process monitoring and control

The PATsmart™ FlowVPE^® System uses the power of Slope Spectroscopy for online process monitoring and PAT fields. Offering process insights and enabling innovation, the FlowVPE helps accelerate development, reduce risk, and increase process efficiency.

Elevate your lab with top-of-the-line consumables tailored for the PATsmart SoloVPE PLUS and PATsmart FlowVPX systems, ensuring pristine measurements and accuracy in your scientific endeavors.

A Unique and Patented Variable Pathlength Technology (VPT)

Providing a more efficient method for analyzing at-line and in-line processes, slope spectroscopy is a UV-based technology that serves as an alternative to the Beer-Lambert Law that focuses on pathlength as the variable that determines concentration.

Our Real-time Process Management (RPM™) Systems establish a new benchmark for real-time process control in downstream bioprocessing by integrating of the PATsmart™ FlowVPX^® in-line UV-Vis spectrophotometer into the KrosFlo^® TFF Systems. This innovative solution empowers users to achieve unparalleled control and optimization of UF/DF processes, driving efficiency, quality, and innovation in biomanufacturing.