Intensification Leader

Intensification delivers more product faster

XCell ATF Technology helps simplify and intensify upstream processes to deliver more product, faster. Intensified processes achieve higher cell densities, require smaller bioreactors and consume less suite time. Increase throughput, productivity, and capacity in both clinical and commercial manufacturing.


XCellATF delivers 10X VCD and lower COGS

Higher productivity and lower COGs for malaria therapeutic candidate.

  • Can deliver 10X VCD more than 2-week Fed- Batch (350 x 10cells/mL) 
  • 50% decrease in bioreactor time
  • 20-fold increase in yield

 Breakthrough technology

How XCell ATF Technology Works

The XCell ATF System is based on award-winning alternating tangential flow (ATF) technology, created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor. Alternating tangential flow is attained by the action of a diaphragm pump.

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 Breakthrough technology

Ready to scale from process development to manufacturing​

The XCell ATF System simplifies and fast-tracks upstream intensification development from PD to commercial scale. Intensification increases throughput, accelerates tech transfer and optimizes your process in clinical manufacturing and MSAT while increasing bioreactor productivity and reducing costs in commercial manufacturing. Higher productivity, smaller bioreactors and higher throughput with shorter times to harvest, combine to mitigate facility expansion risks and capital costs. 

 Integrated system

Design simplicity with XCell® Lab System

Designed and engineered as a complete solution, the XCell Lab System integrates a modern controller, XCell ATF Devices, software and flow sensors into a complete solution.

  • Engineering-designed controller promotes increased intensification
  • Configurable set-up delivers high throughput - a single manifold supports up to 8 XCell ATF Devices
  • Software enables precise technical control with a user-friendly interface
  • New XCell ATF 1 Device is fit for low volume intensification ready for scale-up
  • Repligen global technical support ensures successful implementation and scale-up

XCell™ Lab System


XCell® LS Controller for Pilot and Commercial Manufacturing​

Scaling up from bench scale to commercial scale can be simple with a reliable controller for vital cGMP operations

  • Pairs with single-use and stainless steel XCell ATF 6 and XCell ATF 10 devices, and the stainless steel XCell ATF 4 device​
  • Single LS Controller controls single or dual ATF devices at once​
  • Advanced process monitoring: flow sensor-based control, permeate pressure sensing/filter fouling​
  • Intuitive software with touchscreen interface, 21 CFR part 11 compliant, and Windows 10 Domain security​
  • Operate independently with HMI or integrate with site DCS systems (headless configuration)​
  • Global technical support ensures successful implementation and scale-up




XCell ATF Devices and Controllers

The XCell ATF System delivers a complete solution for upstream intensification with robust hardware software integration. Available in single-use and stainless steel formats with sizes from lab-scale (2 L) to process scale (5000 L). Each system consists of an XCell ATF  Device, XCell Controller, software, tubing and sensors.

XCell ATF Systems

XCell ATF  Cell retention technology simplifies and fast-tracks upstream intensification development for gene therapy, fed-batch intensification, seed train intensification, perfusion, and media exchange applications.  

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The R Factor Video Blog
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Solve the Intensification Puzzle - Faster

The XCell™ Lab Controller solves your productivity puzzle with new engineering, increased throughput and more process data. Turn the frustration of endless permutations into a simple solution that generates more cells, and more product…faster.

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Think outside the blocks

Intensification is worth it. Build an intensified upstream suite brick by brick with XCell ATF® systems. Make twice as much product in half the time as you watch VCD grow and shrink bioreactor sizes within the same facility footprint.

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OMW! with XCell™

OMG life gets busy. Set-up industry-best cell culture intensification in less than 30 minutes with the design simplicity of XCell ATF® devices. Celebrate more product at work…and still have time for the special moments at home. YGTI.

Manufacturing Centers of Excellence

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany, France and Estonia.


Customer First.

Support is part of the Repligen DNA. Our goal is to provide exceptional customer experience, and to support the efficient and successful adoption and implementation of all Repligen products and services.

  • Field Application Support
  • Customer Service
  • Field Service Engineers

Have a question?


Certificate of Quality
View quality documents.


  XCell® ATF 1 Single-use Device XCell® ATF 2 Single-use Device XCell® ATF 4 Stainless Steel Device XCell® ATF 6 Single-use Device XCell® ATF 10 Single-use Device

XCell® ATF 1

XCell® ATF 2

XCell® ATF 4

XCell® ATF 6 XCell® ATF 10
Typical Bioreactor size (L) 0.5 - 2 2 - 10 10 - 50 50 - 200 200 - 1000
Typical pore size SU 0.2µ 0.2µ 0.2µ 0.2µ 0.2µ
Typical pore size SS NA 0.2µ, 0.5µ, 50KDa 0.2µ, 0.5µ, 50KDa 0.2µ, 0.5µ, 50KDa 0.2µ, 0.5µ, 50KDa
Effective surface area (m2) 0.022 0.13 0.77 2.5 11
Filter height (cm) 60 60 30 60 60
Displacement volume (L) 0.017 0.1 0.4 1.3 6
ATF flow range (Lpm) 0.008 - 0.140 0.3 - 1.5 3 - 8 10 - 20 30 - 80
Typical scalable flow/fiber and filtrate rate 12 mL/min/fiber and 4-6 LMH    
Controller Lab Scale Controller

Lab Scale Controller
C410 Controller
LS Controller