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Repligen SpectraFlo Dynamic Dialysis system configured for high‑volume automated buffer exchange and sample purification in bioprocessing applications.

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SpectraFlo™ Dynamic Dialysis Systems

SpectraFlo™ Dynamic Dialysis Systems are the only commercially available systems for scalable dynamic dialysis from lab scale to large volume processing. 

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Product features

Continuous Buffer Flow

No manual buffer changes

Walkaway convenience

Integrated

Includes dialysis tank, pump, reservoirs, membrane

Fast implementation time

Scalable

Scale up from lab to process scale

Scale out from 1 to 6 tanks in series

Increased Purification Efficiency

Sealed self-enclosed design

Minimized exposure to external contaminants

Innovative Mobile System

Large-scale, small footprint

Series operation conserves buffer

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Dynamic Dialysis

Dynamic dialysis is an exciting new technology that utilizes fluid dynamics to increase purification efficiency and improve large buffer handling, ideal for the production of fragile proteins, viscous fluids and polymer gels, such as hyaluronic acid. These closed, high-efficiency systems offer high concentration gradient dialysis without manual buffer changes and in-process sample handling.

SpectraFlo™ Dynamic Dialysis Systems 

SpectraFlo™ Lab System

10-200 ml

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SpectraFlo™ Process System

150 ml - 2 L

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SpectraFlo™ Mobile Dialysis System

6 - 12 L 

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Dynamic Dialysis Applications

Dynamic dialysis is ideal for the purification of viscous fluids and hydrogels (hyaluronic acid – HA) that cannot be filtered. Where traditional filtration methods may fail, dynamic dialysis uses flow dynamics to increase both the rate and efficiency of dialysis.

Applications Why Dynamic Dialysis is preferred Example
Delicate samples Gentle separation without shear stress Labile proteins and intact viruses
Viscous samples (Hyaluronic Acid) Process hydrogels that are too viscous for filtration Cross-linked Hyaluronic Acid for aesthetics and orthobiologics
Protein refolding Refold proteins to native state using gradual pH change through buffer flow Overexpressed proteins containing inclusion bodies
High debris lysate Will not foul like pressure driven filtration Demineralized bone matrix for othopedic surgery
Polymer and Biopolymer synthesis Low MWCO enables removal of unbound low molecular weight monomer Oligonucleotides and polypeptides
Scale up of any static dialysis application Easy scale up without complex validation or financial burden of filtration Desalting

Tank Sizes

SpectraFlo™ Modes of Operation

Case Study: Model of Dynamic Dialysis

This model of a GMP batch production of shear-sensitive protein shows an efficent scale-up of large volume dynamic dialysis for purification. 

SpectraFlo™ Mobile Features and Benefits

FEATURESBENEFITS
Up to 6 tanks in series Scale up to 12L Sample Size
Parallel or series operation Optimize buffer usage
Wet work tray Prepare and load samples with secondary containment
Drain manifold Load and drain buffer easily
BSE/TSE free polypropylene construction Use for GMP processes and cleanroom manufacturing
Collapsible shelves and tubing hooks Store complete system in compact space

Dialysis Membranes

Dialysis membranes from Repligen include biotech-grade, standard-grade and custom membranes that can be used in both lab-scale and process-scale operations.

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Components

KR1 Peristaltic Pump

600 RPM pump-drive with multi-position pump-head

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Processing Reservoirs

Designed with drain and 4 ports for recirculating or reservoirs in series

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Bisectors

Double sample capacity with 2 dialysis tubings in each tank. 

*Tank not included.

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Accessories

Cap Kit

Optional for process system, required for mobile system

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Replacement parts

Pump tubing, gasket sets, hose barbs and stands

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Closure Kit
Universal tubing closures compatible with all dialysis tubing types, designed to provide a leak‑proof seal and required for use with cellulose ester (CE) dialysis membranes.

For proper membrane handing
and support

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Cart Design

Materials of Construction

Quality Specifications

  • USP Class VI biosafety requirements
  • 21 CFR 177.1520
  • Phthalates, BPA and DEHP free
  • BSE/TSE free

Quality Management System-ISO 9001:2015
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