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SpectraFlo™ Dynamic Dialysis Systems

Introducing SpectraFlo™ Dynamic Dialysis Systems, the only commercially available systems for scalable dynamic dialysis from lab scale to large volume processing 

Dynamic Dialysis

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Dynamic dialysis is an exciting new technology that utilizes fluid dynamics to increase purification efficiency and improve large buffer handling, ideal for the production of fragile proteins, viscous fluids and polymer gels, such as hyaluronic acid. These closed, high-efficiency systems offer high concentration gradient dialysis without manual buffer changes and in-process sample handling.

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SpectraFlo™ DYNAMIC DIALYSIS SYSTEMS

SpectraFlo™ Lab and Process Systems

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SpectraFlo™ Mobile Dialysis System

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continuous buffer flow

No manual buffer changes

Walkaway convenience

Fully INtegrated

Includes dialysis tank, pump, reservoirs, membrane

Fast implementation time

scale up, scale out

Scale up from lab to process scale.
Scale out from 1 to 6 tanks in series.

Increased purification efficiency

Sealed self-enclosed design

Minimized exposure to external contaminants

innovative mobile system 

Large-scale, small footprint

Series operation conserves buffer

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SpectraFlo™ Lab System

10-200 ml

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SpectraFlo™ Process System

150 ml - 2 L

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SpectraFlo™ Mobile System

6 - 12 L

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dynamic dialysis applications

Dynamic dialysis is ideal for the purification of viscous fluids and hydrogels (hyaluronic acid – HA) that cannot be filtered. Where traditional filtration methods may fail, dynamic dialysis uses flow dynamics to increase both the rate and efficiency of dialysis.

Applications
Why Dynamic Dialysis is preferred
Example

Delicate samples

Gentle separation without shear stress

Labile proteins and intact viruses

Viscous samples (Hyaluronic Acid)

Process hydrogels that are too viscous for filtration

Cross-linked Hyaluronic Acid for aesthetics and orthobiologics

Protein refolding

Refold proteins to native state using gradual pH
change through buffer flow

Overexpressed proteins containing inclusion bodies

High debris lysate

Will not foul like pressure driven filtration

Demineralized bone matrix for othopedic surgery

Polymer and Biopolymer synthesis

Low MWCO enables removal of unbound low
molecular weight monomer

Oligonucleotides and polypeptides

Scale up of any static dialysis application

Easy scale up without complex validation or
financial burden of filtration

Desalting

 

Tank Sizes

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SpectraFlo™ MODES OF OPERATION

SpectraFlo™ modes of operation

Case Study: model of dynamic dialysis

This model of a GMP batch production of shear-sensitive protein shows an efficent scale-up of large volume dynamic dialysis for purification. 

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SpectraFlo™ MOBILE FEATURES AND BENEFITS

Features
Benefits

Up to 6 tanks in series

Scale up to 12L Sample Size

Parallel or series operation

Optimize buffer usage

Wet work tray

Prepare and load samples with secondary containment

Drain manifold

Load and drain buffer easily

BSE/TSE free polypropylene construction

Use for GMP processes and cleanroom manufacturing

Collapsible shelves and tubing hooks

Store complete system in compact space

 

Dialysis Membranes

 

Dialysis membranes from Repligen include biotech-grade, standard-grade and custom membranes that can be used in both lab-scale and process-scale operations.


DIALYSIS MEMBRANES

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Components and Accessories

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KR1 Peristaltic Pump

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600 RPM pump-drive with multi-position pump-head

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Processing Reservoirs

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Designed with drain and 4 ports for recirculating or reservoirs in series

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Bisectors

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Double sample capacity with 2 dialysis tubings in each tank. *Tank not included.

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Cap Kit

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Optional for process system, required for mobile system

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Replacement parts

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Pump tubing, gasket sets, hose barbs and stands

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Closure Kit

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For proper membrane handing and support
 

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Resources

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