Design your system for flexibility across multiple parameters, such as volume, application, and filter type. Multiple pumps of different sizes augment volume capability. Multiple pump types at different positions expand application and filter type support.
Volume Flexibility
Application Flexibility
Experience the ease and simplicity of designing on-line
See how Repligen systems for tangential flow filtration combine unparalleled configurability with premium quality manufacturing. System designs maximize scalability from small to large volumes, flexibility between hollow fiber and flat sheet filter formats, and ability to use the same system in different unit operations while deploying ready-to-use application-specific flow path assemblies. To ensure success, a team of sales specialists and applications experts helps support rapid start-up and robust operation in cGMP processes.
Includes filters, ProConnex® Flow Path, pumps, process monitors, software and graphic display on a single skid
Small footprint
One system with configurable designs to suit multiple user needs, formats, scale and applications
1 – 5000L volumes, from process development to commercial manufacturing
Ready-to-operate ProConnex® Flow Path - customized, configurable, complete assemblies
Field Applications and Service Specialists provide worldwide support
Membranes, filters and cassettes developed and manufactured in-house at Boston Center of Excellence
Specification |
KrosFlo® KTF Process System |
---|---|
Typical process volumes | Up to 5000 Liters |
Max. filter area | 2 each up to 17.2 m2 (Hollow Fiber) |
Configurable Components | |
Pump | Multiple MagLev pump sizes |
Flow rate | Pumps 1 and 2, up to 85 LMP |
Max. Pressure | 2.5 Bar |
Min. hold up volume | < 0.5 Liter |
Tubing | ≤ 1" ID |
Membranes | Hollow fibers |
Retentate Flow meter Permeate Flow meter |
Clamp-on flow meter Ultrasonic Clamp-on or flow through Ultrasonic |
Feed Scale | Tank 4-20 mA or Ethernet |
Cabinet width | 24" or 30" |
Modes of TFF (Client Base) | Conc, Diaf, Final Conc, Fed Batch+ |
Flow Path | Sterile ProConnex® Flow Path |
TMP control | Non-invasive / No Product Contact |
Pressure sensors | Multiple sizes |
Frame | Stainless Steel 304, <35Ra |
Auxiliary pumps | Tri Lobe SS Perisaltic pump |
Software and HMI | |
PLC | Allen Bradley |
Software | IFix 6.0 iHistorian Dream Reports E-signature |
Delta V | Connectivity to Delta V |
GMP | 21CFR11 Enabled |
Primary Application |
Volume | Inlet/ Outlet | Side Port |
Scale Length |
Effective Length (cm) | Total Length (cm) |
Surface area |
|
---|---|---|---|---|---|---|---|---|
MiniKros |
||||||||
![]() |
Pilot-scale TFF | 5 L - 50 L | 1.5" TC | 0.75" TC | 1 x FL 2 x FL 3 x FL |
20 41.5 65 |
25 46 70 |
0.16 - 0.31 m2 0.32 - 0.65 m2 0.51 - 1.0 m2 |
KrosFlo® |
||||||||
![]() |
Production-scale TFF | 10 – 100L | 3" TC | 1.5" TC | 1 x FL 2 x FL 3 x FL |
20 41.5 65 |
23 46 69 |
0.78 - 1.6 m2 1.65 - 3.25 m2 2.55 - 5.10 m2 |
KrosFlo® MAX |
||||||||
![]() |
Production-scale TFF | 100L – 1000+L | 6" TC | 1.5" TC | R65 3 x FL R85 |
49.9 67.9 107.5 |
73.5 91.5 131.1 |
4.30 - 10.40 m2 7.10 - 17.10 m2 11.30 - 11.35 m2 |
Enhanced through an engineering design process, ProConnex® Flow Paths are customized, configurable and complete assemblies for tangential flow filtration. Designed for use with hollow fiber and/or flat sheet TFF systems, the assemblies are sterile, fit for upstream or downstream processing and manufactured in compliance with ISO guidelines in an ISO 7 clean room.
ProConnex® Configurator
In minutes, using an online drag and drop configurator and with customer input, Repligen representatives can configure a ProConnex® Flow Path specific to a process application in real-time. The output of the ProConnex® Configurator are 3D engineering drawings and a preliminary quote, which greatly expedite the approval, production and delivery of the ProConnex® Flow Path.
Custom flow paths designed in real time in a 3D drag-and-drop environment
|
Experienced account managers with deep industry background act as one point of contact for customers |
|
Technical experts provide membrane and hardware design optimization, and post-sales support for scale-up |
|
Seasoned specialists with application, design and automation knowledge supporting large system projects |
|
Software engineers with application knowledge that support system connectivity with other unit operations |
|
Field-based engineers professionally trained for optimal start-up and post-sales support |
KrosFlo® KTF Pilot and Process Systems are developed, engineered, and manufactured at the Repligen Manufacturing Center of Excellence in Boston, Massachusetts. In this facility, both membranes and systems are produced under the same roof, complemented with R&D expertise on membrane applications. Customers routinely come to the site for demonstrations and training.
Systems Center of Excellence - Boston, MA
Membrane manufacturing
Systems manufacturing
Training area
Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.
*Final design configured to customer application
Configure your krosflo® ktf system
Specification |
KrosFlo® KTF Pilot System |
---|---|
Typical process volumes | Up to 1000L |
Max. filter area | 17.2 m2 (Hollow Fiber) |
Configurable Components | |
Pump | MagLev 600 Series |
Flow rate | Pumps 45 LMP |
Max. Pressure | 2.0 Bar |
Min. hold up volume | 2.0 Liter |
Tubing | 3/4" ID |
Membranes | Hollow fibers |
Retentate Flow meter Permeate Flow meter |
Clamp-on flow meter Ultrasonic Clamp-on or flow through Ultrasonic |
Feed Scale | Platforms Available and Client 4-20mA |
Cabinet width | 24" |
Modes of TFF (Client Base) | Conc, Diaf, Final Conc, Fed Batch+ |
Flow Path | Sterile ProConnex® |
TMP control | Non-invasive / No Product Contact |
Pressure sensor | 0.5" and 1.0" Polysulfone Single-Use |
Frame | Stainless Steel 304, <35Ra |
Auxiliary pumps | Tri Lobe SS Perisaltic pump |
Software and HMI | |
PLC | Allen Bradley |
Software | IFix 6.0 iHistorian Dream Reports E-signature |
Delta V | Connectivity to Delta V |
GMP | 21CFR11 Enabled |
*Final design configured to customer application
Configure your krosflo® ktf system
Specification |
KrosFlo® KTF Process System |
---|---|
Typical process volumes | Up to 5000L |
Max. filter area | 2 each up t0 17.2 m2 (Hollow Fiber) |
Configurable Components | |
Pump | MagLev 2 each 2000 Series |
Flow rate | Pumps 1 and 2: 85 LMP |
Max. Pressure | 2.5 Bar |
Min. hold up volume | 6 Liter |
Tubing | 1" ID |
Membranes | X Series Hollow fibers |
Retentate Flow meter Permeate Flow meter |
Clamp-on flow meter Ultrasonic Clamp-on or flow through Ultrasonic |
Feed Scale | Tank 4-20 mA or Ethernet |
Cabinet width | 30" |
Modes of TFF (Client Base) | Conc, Diaf, Final Conc, Fed Batch+ |
Flow Path | Sterile ProConnex® |
TMP control | Non-invasive / No Product Contact |
Pressure sensor | 1.0" and 1.38" Sanitary Polysulfone Single-Use |
Frame | Stainless Steel 304, <35Ra |
Auxiliary pumps | Tri Lobe SS Perisaltic pump |
Software and HMI | |
PLC | Allen Bradley |
Software | IFix 6.0 iHistorian Dream Reports E-signature |
Delta V | Connectivity to Delta V |
GMP | 21CFR11 Enabled |
KrosFlo® KTF 200 |
KrosFlo® KTF 600 |
KrosFlo® KTF 1000 |
|
Typical process volumes | Up to 200L | Up to 1000L | Up to 2500L |
Max. filter area | 1.0m2 (Hollow Fiber) | 17.2m2 (Hollow Fiber) | 17.2m2 (Hollow Fiber) |
Configurable components | |||
Pump | MagLev x 1 (i100) | MagLev x 1 (600 Series) | MagLev x 1 (2000 Series) |
Flow rate | Pump 1: 10 LPM | Pump 1: 45 LPM | Pump 1: 85 LPM |
Max. pressure | 1.5 Bar | 2.0 Bar | 2.5 Bar |
Min. hold up volume | 200 ml | 2000 ml | 3500 ml |
Tubing Connections to Tank | 3/8" ID | 3/4" ID | 1" and 3/4" ID |
Hollow Fiber Filter | N filter modules | N, K, X filter modules | X filter modules |
Retentate Flow meter | Clamp-on flow Ultrasonic |
✓ |
✓ |
Feed Scale or Client Signal (4-20mA) | Platform 220kg | Paltform 500kg, 1000kg, 2000kg | Platform 2000kg+ |
Frame Width | 24" | 24" | 24" |
Modes of TFF | Conc, Diaf, Final Conc, Fed Batch+ |
✓ |
✓ |
Flow-Path | Sterile ProConnex® Flow Path |
✓ |
✓ |
TMP Control | Non-invasive value |
✓ |
✓ |
Single-Use Pressure Sensor | Sanitary PS 0.5", 1.0", 1.38" |
✓ |
✓ |
Frame | Stainless Steel 304, < 35Ra |
✓ |
✓ |
Permeate Pump | Tri lobe Peristaltic pump |
✓ |
✓ |
Software and HMI | |||
HMI |
Rockwell 6181P HMI/ Windows 10 | ✓ | ✓ |
PLC | Allen Bradley Micrologix 1400 |
✓ |
✓ |
Software | IFix 6.0 iHistorian Dream Reports E-signature |
✓ |
✓ |
GMP | Enables 21CFR11 |
✓ |
✓ |
Delta V | Connectivity to Delta V |
✓ |
✓ |
Permeate Flow Meter | Clamp-on or Flow Thru Ultrasonic |
✓ |
✓ |
|
KrosFlo® KTF 650 |
KrosFlo® KTF 700 |
KrosFlo® KTF 1600 |
KrosFlo® KTF 2000 |
Typical process volumes | Up to 1000L | Up to 1000L | Up to 2500L | Up to 5000L |
Max. filter area | 17.2m2 (Hollow Fiber) | 17.2m2 (Hollow Fiber) | 17.2m2 (Hollow Fiber) | 17.2m2 (Hollow Fiber) x 2 |
Configurable components | ||||
Pump | MagLev x 2 | MagLev x 2 | MagLev x 2 | MagLev x 2 |
Flow rate | Pump 1: 4 LPM Pump 2: 45 LPM |
Pump 1: 10 LPM Pump 2: 45 LPM |
Pump 1: 45 LPM Pump 2: 85 LPM |
Pumps 1 and 2: 85 LPM |
Max. pressure | 1.5 Bar | 2.0 Bar | 2.5 Bar | 2.5 Bar |
Min. hold up volume | 375 ml | 750 ml | 4500 ml | 6000 ml |
Tubing Connections to Tank | 1/4" and 3/4" ID | 3/8" and 3/4" ID | 1" and 3/4" ID | 1" ID |
Hollow Fiber Filter | T,S,N,K,X filter modules | S,N,K X filter modules | K,X filter modules | X filter modules |
Retentate Flow meter | Clamp-on flow Ultrasonic |
✓ |
✓ |
✓ |
Feed Scale or Client Signal (4-20mA) |
Platform 220kg, 500kg, 2000kg | Paltform 200kg, 500kg, 2000kg | Platform 1000kg+ | Platorm 2000kg+ |
Frame Width | 30" | ✓ | ✓ | ✓ |
Modes of TFF | Conc, Diaf, Final Conc, Fed Batch+ |
✓ |
✓ |
✓ |
Flow-Path | Sterile ProConnex® Flow Path |
✓ |
✓ |
✓ |
TMP Control | Non-invasive value |
✓ |
✓ |
✓ |
Single-Use Pressure Sensor | Sanitary PS 0.5", 1.0", 1.38" |
✓ |
✓ |
✓ |
Frame | Stainless Steel 304, < 35Ra |
✓ |
✓ |
✓ |
Permeate Pump | Tri lobe Peristaltic pump |
✓ |
✓ |
✓ |
Software and HMI | ||||
HMI | Rockwell 6181P HMI/Windows 10 | ✓ | ✓ | ✓ |
PLC | Allen Bradley Micrologix 1400 |
✓ |
✓ |
✓ |
Software | IFix 6.0 iHistorian Dream Reports E-signature |
✓ |
✓ |
✓ |
GMP | Enables 21CFR11 |
✓ |
✓ |
✓ |
Delta V | Connectivity to Delta V |
✓ |
✓ |
✓ |
Permeate Flow Meter | Clamp-on or Flow Through Ultrasonic |
✓ |
✓ |
✓ |
|
|
---|---|
Base Control Platform | iFIX 6.0 Software, 300 tags |
Batch Reports | Dream Report® |
Security / Trends | Windows® 10 with optional E-signature with iHistorian |
PLC | Allen Bradley® PLC Micrologix 1400 |
Communication | Direct to iFIX:
|
Interface Options |
Remote control via Ethernet IP
|
Regulatory | 21CFR11 Enabled - Compliance and Documentation, including Audit Trail |
Process Sequence | Sequence programmed to Process Requirements |