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TangenX® Hardware

TangenX® hardware are designed for use with TangenX® filter cassettes and disc membranes for tangential flow filtration.

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Cassette Clamps

TangenX® SIUS® Cassette Clamps are composed of two stainless steel plates that are isolated from any contact with the process fluid. They are designed to be used with TangenX® SIUS® and SIUS® PD Cassettes and filter plate inserts.

TangenX™ SIUS™ PD Horizontal Cassette Clamp

TangenX® SIUS® PD
Horizontal Cassette Clamp

TSLDI-2BMC (Clamp)
TFPLS-SA08 (Filter Plate)

TangenX™ SIUS™ Horizontal Cassette Clamp

TangenX® SIUS®
Horizontal Cassette Clamp

TSPDI-4BMC (Clamp)
TFP75-SE16 (Filter Plate)

TangenX™ SIUS™  Vertical Cassette Clamp

TangenX® SIUS®
Vertical Cassette Clamp

TSPDI-V2BC (Clamp)
TFP99-SP20 (Filter Plate)


Filter Plate Inserts

Combining TangenX® SIUS® Cassettes with a single-use TangenX® SIUS® Filter Plate Insert creates a complete assembly for single-use tangential flow filtration (TFF).


Pre-sanitized, ready to use with TangenX® SIUS® Single-use Cassettes


With TangenX® SIUS® cassette clamps and traditional holders and hardware


SIUS™ assembly
TangenX™ SIUS™ PD Filter Plate Insert


TangenX® SIUS® PD Filter Plate Insert


  • 0.01 to 0.1 m2 x 5
  • 1/2" mini TC
TangenX™ SIUS™ Filter Plate Insert

TangenX® SIUS® Filter Plate Insert


  • 0.5 to 5.0 m2 up to 49 LPM
  • 1" TC (4) ports

TangenX® SIUS® LV Filter Plate Insert


  • 0.01 - 0.02 m2
  • Luer Lock

KrosFlo® TFF Systems

TangenX® SIUS® Flat Sheet Cassettes are integrated in lab-scale and pilot-scale KrosFlo® TFF Systems.


Cassette Holders

Engineered for optimal performance, TangenX® PRO stainless steel cassette holders are designed for optimal performance with TangenX® PRO and PRO PD Reusable TFF Cassetes.

  • Feed and retentate ports match the geometry of TangenX® cassettes
  • Better fluid dynamics allow for higher flow-rates and reduced hold-up volumes
  • Less-restrictive port design ensures safe processing with higher yields
  • Ports  are compatible with tri-clover, quick-disconnect, sanitary fittings and pharmaceutical-grade gauges that allow connections to be made easily between the holder and supporting equipment.

Made from 316 L stainless steel to precise specifications, the holders feature a 20 RA finish on all wetted surfaces. The exterior is electropolished to 32 RA providing a highly polished mirror finish. The holders are compatible with acids, bases and a variety of other cleaning agents.



Identical fluid flow-path channels enable easy, direct scale-up/scale-down between TangenX™ PRO and PRO PD Cassettes

Easy clean-in-place capability
Easy clean-in-place 

Steam-sterilizable or autoclavable without cassettes


Sanitary fittings and gauge packages available to create a complete sanitary system

TangenX™ PRO PD Horizontal Holder

TangenX® PRO PD Horizontal Holder

TX003 (Pilot Holder)

  • Expands to accommodate from 0.01 to 0.5 m2 (1 to 5 ft2) of screen channel or suspended screen channel cassettes
  • Available with luer lock for reduced hold up volume or mini tri-clamp connections for sanitary applications
TangenX™ PRO PD Vertical Cassette Holder

TangenX® PRO PD Vertical Cassettes Holder

TX034 (HC-LHV Holder with stand and 3-gauge Fitting Package)

  • Enhanced drainability
  • Reduced footprint and efficient use of limited laboratory space
TangenX™ PRO Horizontal Cassette Holder

TangenX® PRO Horizontal Cassette Holder

TX032 (Horizontal Sanitary Holder Version 2)

  • Expands to accommodate from 0.46 to 6 m2 (% to 50 ft2) of screen channel or suspended screen channel cassettes
  • Smaller footprint means lower capital and operational costs, and efficient use of limited production space
TangenX™ PRO Vertical Cassette Holder

TangenX® PRO Vertical Cassette Holder

TX005 (Vertical Sanitary Holder with Auto Torque)

  • Enhanced drainability 
  • Available with hydraulic auto-torque closing option
    • Minimizes the difficulty and time associated with loading large area systems
    • Prevents cassette misalignment and potential leakage
    • Single-sided vertical design allows for easy cassette installation and change
    • Eliminated operator torque variability


The X-Flo76 Membrane Screening System utilizes 76 mm membrane discs to determine the most advantageous balance of selectivity and flux.

Traditional membrane screening is performed using stirred cells, which is not representative of the cross-flow or trans-membrane pressure (TMP) conditions in membrane cassette devices.

In the X-Flo76 System, a patented spiral flow path allows fluid to be directed across the surface of the membrane, creating cross-flow shear conditions that are more representative of true scale-up. Unlike traditional stirred cells, the X-Flo76 uses a pump as the filtration driving force for better TMP control and optimal scale-up  performance. Watch the video to see the XFlo-76 System in operation.

  • Efficient predictable membrane screening
  • Representative tangential flow characteristics
  • Convenient processing of 15-500 mL
  • Quick easy assembly (Area: 30 cm2)
X-Flo76 labeled diagram