KrosFlo KR2i and KrosFlo KMPi Flow Paths ​

The convenience of off-the-shelf flow paths designed specifically to run Spectrum® Hollow Fiber or TangenX® flat sheet cassettes on the KrosFlo KR2i and KMPi systems. Filter sold separately.

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Design Your Own​

Configure a KrosFlo KR2i or KrosFlo KMPi flow path to meet specific process requirements. Includes quality documentation and free consultation.​

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Custom KrosFlo KR2i ProConnex Flow Path

 

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You don’t mind the work of assembling your own flow path. Our selection of connectors, pressure sensors, tubing and vessels could be the solution for you.​

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KrosFlo FS-15 and FS-500 Flow Paths ​

Off-the-shelf flow paths offer convenience, reliability and quality documentation for flat sheet cassettes run on FS systems. No more cutting tubing, component searching, documentation and inconsistent setup. Filter sold separately.

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Design Your Own​

Configure a FS flow path to meet specific process requirements. Includes quality documentation and free consultations.

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Custom KrosFlo KR2i ProConnex Flow Path

 

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You don’t mind the work of assembling your own flow path. Our selection of connectors, pressure sensors, tubing and vessels could be the solution for you.​

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KrosFlo TFDF Lab Flow Paths

Off-the shelf, single-use, gamma-irradiated and closed TFDF Lab Flow Paths arrive dry, free of sodium hydroxide, glycerin, preservative and ethanol, for a zero flush start state.

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Custom KrosFlo TFDF Pilot and Process Flow Paths

When scaling up, configure a flow path to meet your process requirements for your pilot and process KrosFlo TFDF Systems. All KrosFlo TFDF flow paths are single-use, gamma-irradiated and arrive dry, free of sodium hydroxide, glycerin, preservative and ethanol, for a zero flush start state.

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KrosFlo KTF Flow Paths

Configure a flow path for either Spectrum Hollow Fibers or TangenX flat sheet cassettes that matches the design of your KrosFlo system.​

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KRM Chromatograhy System Flow Paths

Highly optimized, low hold-up volume flow paths that utilize innovative technologies like overmolded connections and injection molded intersections for optimal fluid dynamics on the advanced KRM Chromatography Systems.​

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KrosFlo RS TFF System Flow Path

Highly optimized, low hold-up volume flow paths that utilize innovative technologies like overmolded connections and injection molded intersections for optimal fluid dynamics on the highly automated KrosFlo RS Systems.​

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SYSTEM FLOW PATHS

Save time, streamline operations and hit the ground running

These off-the-shelf flow path solutions offered by Repligen deliver wins for the customers every step of the way.

 SYSTEM FLOW PATHS

High quality standard to minimize regulatory burden​ 

BIO USP <88> TSE/BSE

  • The fluid path of this single use fluid transfer system has passed USP class VI (USP<88>) and EMA/410/01

PARTICULATE USP <788>

  • Current USP standard for allowable visible and subvisible particulate for medical infusions an injections

ENDOTOXIN USP <85>

  • Current standard for quantification of endotoxin, Aqueous extracts from representatives samples contained <0.25 EU/mL

STERILITY ANSI/AAMI/ISO 11137

  • Validated following ANSI/AAMI/ISO 11137 guidelines for VDmax25 to provide a minimum sterility assurance level (SAL) for 10-6 for
CONFIGURABLE FLOW PATHS

Flow paths engineered to user specifications and requirements​

Leverage a library of over 300 individual components and expert support to turn specific process requirements into an optimal flow path in no time.​

Get the most out of the process and Repligen system while maintaining sterility and still being plug and play.

These custom configured flow path are supplied fully assembled, complete with accessories and filters.

Speak to an Expert

  CONFIGURABLE FLOW PATHS

Technical consultation from concept to product 

With decades of experience, Repligen technical experts match your core technology with the flow paths that suit your application.

Process goals
Core technology, application, facility fit

Process parameters
Feed flow rate​, working volume​ and pressure​, integrity test​, sterility​, scale

Flow path requirements
Aseptic connectors​, sensors​, vessel​, hold-up volume 

Flow path specifications
Engineering documents​, bill of materials​, design lock

High-Capacity, Globalized Manufacturing and Supply Chain​

A supply chain that prioritizes best-in-class lead times and 95% on time delivery by designing for robustness, redundancy and risk mitigation. System specific flow paths and certain hollow fiber filters are stocked and available off-the-shelf. ​

Membrane and module manufacturing

  • Multi-lane
  • Multi-site
  • Dual continent

Assembly and gamma radiation

  • Multi-lane, multi-site, and dual-continent assumbly centers
  • Multi-cell and multi-site gamma radiation with 2 independant partners

Packaging and logistics 

  • Continuous improvement programs
  • ISTA3A certified packaging process
  • Networked and regional distribution
  • Sustainability programs

Key Specifications for System Flow Paths​ 

Below are the key specifications for system flow paths. To see specifications for KrosFlo® KTF and RS TFF Systems or the KRM™ Chromatography System, please contact a sales representative.​

DescriptionHollow Fiber Ready KR2i Tube Sets Flat Sheet Ready KR2i Tube sets FS-15 Flat Sheet Ready Flow Paths FS-500 Flat Sheet Ready Flow Paths
SystemKR2i KR2i FS15 FS500
Compatible withHF Modules C, D, T, S TFPLS-SA08 & TFPLS-LVFL - -
FPI Connectors- - 1/2" TC 1 - 1/2" TC
Reservoir Connectors - - 1/2" TC 1/2" TC
Reservoir Size 15 mL - 1 L 250 mL - 2 L - -
Pump Tubing (Feed, Addition) Pharmapure #14 - #25 Pharmapure #16 - #25 Silicone #17; #25; Reinforced .25" ID Silicone #82; #36; Reinforced .50" ID
Retentate and Permeate Tubing Silicone #14 - #25 Pharmapure #16 - #25 Silicone #17 & Reinforced Silicone 0.25" ID Silicone #82; #26; Reinforced Silicone 0.5" ID
Delivery Condition Sterile Irradiated Non-irradiated Non-irradiated
Hold-up Volume 0.3 mL - 40 mL 5 mL - 60 mL 75 mL 300 mL
Part Number STUBEGN16315N STUBEGN16316N
ProConnex TFDF Flow PathLab-scale Lab-scaleLab-scalePilot-scale Process-scale
TypeFilter Flow path Flow path Flow path Flow path
Surface Area (cm2)3, 30 3, 30, 50 150 450, 750, 1500 2100, 6000
Fibers1 1 1 3, 5, 10 14, 40
Total Fiber Length (cm) 20 20, 36 108 108 108
Effective Length (cm) 2, 20 2, 20, 36 108 108 108
Number of Tubes 1 1 1 3, 5, 10 14, 40
Standard configuration made to stock Yes Yes Yes No No
Customizable N/A Yes Yes Yes Yes
Part Number TFDF-3, TFDF-30 STFDFCL15110S, STFDFCL15546S, STFDFCL15111S STFDFCL15112S - -

Manufacturing Centers of Excellence

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.

Locations

Customer First.

Support is part of the Repligen DNA. Our goal is to provide exceptional customer experience, and to support the efficient and successful adoption and implementation of all Repligen products and services.

  • Field Application Support
  • Customer Service
  • Field Service Engineers

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