OPTIMIZED

Menu-driven Software for Optimized TFF

KF Comm 2 Software, backward compatible with legacy KrosFlo® KR2i and KrosFlo® KMPi Systems, is conveniently installed on any computer using the Windows Operating System. The software is compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers and is always current with automatic software and firmware updates. 

  • Proprietary software optimized for KrosFlo® TFF Systems
  • Validated for GMP Processes with optional 21 CFR Part 11 option
  • Intuitive workflow with 13 modes of operation
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 21 CFR Part 11 option

Optional GMP Validation

KF Comm 2 software may be validated for GMP processes with optional 21 CFR Part 11 compliance.

  • Available for customers that require the system to be validated for GMP processes

  • Includes user-specific access control via an administration console 

  • Login module with electronic signature that logs when the user is running experiments and accessing archived data

  • Audit Trail /Auditor role

KF Comm 2 Software

KF Comm 2 Software

  • Automatically collects process data
  • Provides real-time overviews of the filtration process

Microsoft Surface Pro 4

  • Automatically graphs data and trends in the software

Real-time operating parameters

  • Time
  • Feed Pressure
  • Retentate Pressure
  • Permeate Pressure
  • Feed Flow Rate
  • Diafiltration Flow Rate
  • Permeate Flow Rate 
  • Feed Scale Weight
  • Permeate Scale Weight
  • Pump RPM
  • Notes (Alarms, Process status, Functions)
  • Pump Mode

Processing parameters

  • Transmembrane Pressure (TMP)
  • Pressure Drop (ΔP)
  • Retentate Flow Rate
  • Permeate Flux
  • Volumetric Throughput (VT)
  • Concentration Factor
  • Shear
  • Diafiltration Volumes
  • Process Time
  • UV, Conductivity, and Temperature (with KONDUiT)

13 Modes of Operation

Process Control Modes Primary Application
MManual Mode Manual operation of pumps and auxiliary components
CONT Continuous Mode Manual operation of pumps and auxiliary components with operator interface step of operation (concentration and diafiltration)
C Concentration Mode Simple concentration of the process solution. Automated flushing of the hollow fiber filter
C/D Concentration / Diafiltration Concentration and then diafiltration of the process solution in succession
C/D/C Concentration / Diafiltration / Concentration Diafiltration of the process solution with one buffer before concentration of the process solution a second time
C/D/D/C Concentration / Diafiltration / Diafiltration / Concentration Diafiltration of the process solution with two different buffers in succession before concentration of the process solution a second time
CFC Constant Feed Concentration Concentration of the solution while maintaining a constant feed weight
CF/D/C Constant Feed Concentration / Diafiltration / Concentration Concentration of the solution while maintaining a constant feed weight, then washing the solution with a buffer during diafiltration, followed by further concentration of the solution
V *NEW* Control mode (Vacuum Mode) Use Constant Feed Mode and/or Diafiltration Mode without the need of auxiliary pumps. The solution is drawn into the Feed reservoir by the vacuum created in the reservoir as the solution permeates out of the filter
F *NEW* Flushing Mode Flush mode
NWP *NEW* Normalized Water Permeability Mode Used to determine filter cleanliness after cleaning and used to determine the water flux of a new module
C *NEW* Cleaning Mode Clean mode
FE *NEW* Flux Excursion Mode Measure flux rate

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Customer First.

Support is part of the Repligen DNA. Our goal is to provide exceptional customer experience, and to support the efficient and successful adoption and implementation of all Repligen products and services.

  • Field Application Support
  • Customer Service
  • Field Service Engineers

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