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XCell ATF® Technology

XCell ATF® intensification solves upstream manufacturing capacity, productivity, and throughput challenges.

Icon_NEW.jpg  XCell™ Lab System 

Designed and engineered as a complete solution, the XCell™ Lab System integrates a modern controller, XCell ATF® Devices, software and flow sensors into a complete solution. 

  • Engineering-designed controller promotes increased intensification
  • Configurable set-up delivers high throughput - a single manifold supports up to 8 XCell ATF® devices
  • Software enables precise technical control with a user-friendly interface
  • New XCell ATF® 1 Device is fit for low volume intensification ready for scale-up
  • Repligen global technical support ensures successful implementation and scale-up
     

XCell™ Lab System

intensification Delivers more Product Faster 

XCell ATF® technology helps simplify and intensify upstream processes to deliver more product, faster. Intensified processes achieve higher cell densities, require smaller bioreactors and consume less suite time. Increase throughput, productivity, and capacity in both clinical and commercial manufacturing.

DELIVER MORE, ​FASTER

Increase throughput​
More programs, ​more molecules​

Increase productivity ​
More product per batch​

Increase capacity ​
More batches per facility

Execute high roi ​BUSINESS DECISIONS

Reduce bioreactor size up to 10 fold
For example from 10,000 L to 1,000 L

Advance your program
Smaller, flexible intensified processes

Re-think your facility
Lower cost​, lower risk​, faster results

XCell™ Lab Controller

Design simplicity
Software, hardware, device

Precision pumping
enables robust development

More process data
for improved characterization

Reduced media cost

XCell ATF®, a leading cell retention technology, simplifies and fast-tracks upstream intensification development for gene therapy, fed-batch intensification, seed train intensification, perfusion, and media exchange applications.  

XCell ATF® by application

XCell ATF® intensification from Process development to manufacturing​

The XCell ATF® intensification simplifies and fast-tracks upstream intensification development from PD to commercial scale. Intensification increases throughput, accelerates tech transfer and optimizes your process in clinical manufacturing and MSAT while increasing bioreactor productivity and reducing costs in commercial manufacturing. Higher productivity, smaller bioreactors and higher throughput with shorter times to harvest, combine to mitigate facility expansion risks and capital costs. 

XCell Atf® in Gene Therapy and Adenovirus

The XCell ATF® solution delivers an efficiency boost both pre- and post-transfection in the gene therapy workflow. Increase yield and save time during host cell expansion and pre-transfection preparation. Post-transfection options exist for multiple host types.

Gene Therapy Manufacturing 2.0  

 

AAV Production

  • Boost output
  • Save time

Adenovirus and Vaccine Production

  • Boost output
  • Produce clarified harvest
  • Go straight to downstream

Xcell ATF® Delivers 10x VCD and Lowers cogs

Source: ExpreS2ion Technologies

Higher productivity and lower COGs for malaria therapeutic candidate.

  • 10X VCD more than 2-week Fed- Batch (350 x 106 cells/mL) 
  • 50% decrease in bioreactor time
  • 20-fold increase in yield

How XCell ATF® Technology works

The XCell ATF® System is based on award-winning alternating tangential flow (ATF) technology, created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor. Alternating tangential flow is attained by the action of a diaphragm pump.

XCell ATF® Devices and controllers

The XCell ATF® System delivers a complete solution for upstream intensification with robust hardware software integration. Available in single-use and stainless steel formats with sizes from lab-scale (2 L) to process scale (5000 L). Each system consists of an XCell ATF® Device, XCell™ controller, software, tubing and sensors.

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system.  We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

about repligen manufacturing

REPLIGEN technical support ENSUres Success

The Repligen Field Application team with expertise in XCell ATF® technology will provide support from consultation to implementation globally. 

Consultation

  • Theory
  • Technology fit
  • Experimental plan

Evaluation

  • Demonstration
  • Training
  • Data analysis

Development

  • Optimization
  • Flow Path sizing
  • System sizing

Implementation

  • Scale-up
  • Validation
  • Long-term training plan

Resources

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Frequently asked questions | perfusion