products
XCell® ATF Systems
SIMPLIFY AND INTENSIFY
XCell® ATF Systems attach to a bioreactor to intensify upstream manufacturing capacity, productivity, and throughput.
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product features
Intensification leader
Breakthrough technology
Integrated system
Intensification Leader
Intensification delivers more product faster
XCell ATF Technology helps simplify and intensify upstream processes to deliver more product, faster. Intensified processes achieve higher cell densities, require smaller bioreactors and consume less suite time. Increase throughput, productivity, and capacity in both clinical and commercial manufacturing.
Boost Upstream Productivity with N-1 and N-Stage Perfusion
Biologics demand is outpacing upstream capacity, and teams need practical, low-risk strategies to increase output within existing fed-batch facilities. Perfusion-based process intensification offers two proven strategies to increase productivity and lower COGs.
- N-stage perfusion maximizes productivity and reduces upstream COG
- N-1 perfusion accelerates fed-batch timelines with higher-density inoculation
- Both approaches are scalable and widely adopted across leading upstream cell culture processes at all scales
INTENSIFICATION LEADER
XCell ATF delivers 10X VCD and lower COGS
Higher productivity and lower COGs for malaria therapeutic candidate.
- Can deliver 10X VCD more than 2-week Fed- Batch (350 x 106 cells/mL)
- 50% decrease in bioreactor time
- 20-fold increase in yield
Breakthrough technology
How XCell ATF Technology Works
The XCell ATF System is based on award-winning alternating tangential flow (ATF) technology, created by the action of a diaphragm moving upward and downward within a pump head, connected to a filter housing and attached to a bioreactor. Alternating tangential flow is attained by the action of a diaphragm pump.
Breakthrough technology
Ready to scale from process development to manufacturing
The XCell ATF System simplifies and fast-tracks upstream intensification development from PD to commercial scale. Intensification increases throughput, accelerates tech transfer and optimizes your process in clinical manufacturing and MSAT while increasing bioreactor productivity and reducing costs in commercial manufacturing. Higher productivity, smaller bioreactors and higher throughput with shorter times to harvest, combine to mitigate facility expansion risks and capital costs.
Integrated system
Design simplicity with XCell® Lab System
Designed and engineered as a complete solution, the XCell Lab System integrates a modern controller, XCell ATF Devices, software and flow sensors into a complete solution.
- Engineering-designed controller promotes increased intensification
- Configurable set-up delivers high throughput - a single manifold supports up to 8 XCell ATF Devices
- Software enables precise technical control with a user-friendly interface
- New XCell ATF 1 Device is fit for low volume intensification ready for scale-up
- Repligen global technical support ensures successful implementation and scale-up
XCell® LS Controller for Pilot and Commercial Manufacturing
Scaling up from bench scale to commercial scale can be simple with a reliable controller for vital cGMP operations
- Pairs with single-use and stainless steel XCell ATF 6 and XCell ATF 10 devices, and the stainless steel XCell ATF 4 device
- Single LS Controller controls single or dual ATF devices at once
- Advanced process monitoring: flow sensor-based control, permeate pressure sensing/filter fouling
- Intuitive software with touchscreen interface, 21 CFR part 11 compliant, and Windows 10 Domain security
- Operate independently with HMI or integrate with site DCS systems (headless configuration)
- Global technical support ensures successful implementation and scale-up
XCell ATF Devices and Controllers
The XCell ATF System delivers a complete solution for upstream intensification with robust hardware software integration. Available in single-use and stainless steel formats with sizes from lab-scale (2 L) to process scale (5000 L). Each system consists of an XCell ATF Device, XCell Controller, software, tubing and sensors.
XCell ATF Systems
XCell ATF Cell retention technology simplifies and fast-tracks upstream intensification development for gene therapy, fed-batch intensification, seed train intensification, perfusion, and media exchange applications.
Resources
Specifications
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XCell® ATF 1 |
XCell® ATF 2 |
XCell® ATF 4 |
XCell® ATF 6 | XCell® ATF 10 | |
| Typical Bioreactor size (L) | 0.5 - 2 | 2 - 10 | 10 - 50 | 50 - 200 | 200 - 5000 |
| Format | SU | SU, SS | SS | SU, SS | SU, SS |
| Chemistry | PES | PES, PS | PES, PS | PES, PS | PES, PS |
| Typical pore size SU | 0.2µ | 0.2µ | 0.2µ | 0.2µ | 0.2µ |
| Typical pore size SS | NA | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa | 0.2µ, 0.5µ, 50KDa |
| Effective surface area (m2) | 0.022 | 0.13 | 0.77 | 2.5 | 11 |
| Filter height (cm) | 60 | 60 | 30 | 60 | 60 |
| Displacement volume (L) | 0.017 | 0.1 | 0.4 | 1.3 | 6 |
| ATF flow range (Lpm) | 0.008 - 0.140 | 0.4 - 1.5 | 3 - 8 | 10 - 20 | 30 - 80 |
| Typical scalable flow/fiber and filtrate rate | 12 mL/min/fiber and 4-6 LMH | ||||
| Controller | Lab Scale Controller | Lab Scale Controller C410 Controller LS Controller |
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