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Quantitation of Nucleic Acids
The PATsmart SoloVPE System has been proven to be accurate, precise, and robust for the quantitation of nucleic acids, such as DNA, RNA, and Oligonucleotide.
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Repligen Reports Fourth Quarter and Fiscal Year 2011 Financial Results and Updates Expectations and Corporate Goals for Fiscal Year 2012
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Repligen Reports Preliminary Fiscal Year 2011 Financial Results and Financial Guidance and Development Goals for Fiscal Year 2012
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Evaluation and Comparison of Tangential Flow Filtration Cassettes for Use in a Monoclonal Antibody Purification Process
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Repligen Corporation Announces Proposed Public Offering of Shares of Common Stock
WALTHAM, Mass., April 29, 2019 (GLOBE NEWSWIRE) - Repligen Corporation (NASDAQ: RGEN) today announced that it has commenced an underwritten public offering of $175,000,000 in shares of its common stock. In addition, Repligen Corporation expects to grant the underwriters a 30-day option to purchase up to an additional $26,250,000 in shares of its common stock in connection with the proposed public offering. All shares of common stock will be offered by Repligen Corporation. Repligen Corporation expects to use the net proceeds to fund the cash portion of the purchase price for its previously announced proposed acquisition of C Technologies, Inc. and for working capital and other general corporate purposes. J.P. Morgan Securities LLC and Stephens Inc. are acting as joint book-running managers for the offering. Janney Montgomery Scott is acting as lead manager for the offering. The offering is subject to market and other conditions, and there can be no assurance as to whether or when the
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Application of Variable Pathlength Technology for Rapid Determination of Dynamic Binding Capacity (KBI Biopharma)
An ever-increasing demand for biomolecule-based therapies is driving biopharmaceutical companies to accelerate process development activities to remain competitive in today’s industry. Within the downstream process development space, affinity chromatography is widely used for primary capture of monoclonal antibodies, Fc fusion proteins, etc. Optimization of this step requires determination of dynamic binding capacity (DBC) for target protein molecule and can be a lengthy process using traditional methods. KBI Biopharma has applied the use of variable pathlength technology for rapid generation of breakthrough curves and determination of DBC for capture resin selection. FlowVPE, a variable pathlength UV detector from Repligen, is integrated with the chromatographic system for real time generation of breakthrough curves, reducing the time and cost associated with the development of the primary capture step. This technology helps accelerate the overall process development timeline. Speaker: Rashmi Bhangale, Ph.D., Downstream Process Development Scientist – KBI Biopharma.
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Drug-to-antibody Ratio (DAR)
The SoloVPE System provides accurate, precise, and robust concentration measurements of Antibody-Drug Conjugates (ADCs) and Drug-to-Antibody Ratio (DAR).
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Repligen Reports Preliminary Fiscal Year 2010 Financial Results and Provides Financial Guidance and Development Goals for Fiscal Year 2011
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Charge Variant Analysis
Challenge: Charge heterogeneity in early development can affect efficacy and safety, but typical offline CEX or IEF methods are low throughput. Our Solution: ZipChip CE offers fast, high-resolution separation of charge variants to assess product consistency before scale-up.
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A Brief History of Perfusion Biomanufacturing: How High-Concentration Cultures Will Characterize the Factory of the Future
By John Bonham-Carter and Jerry Shevitz BioProcess International
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