The R Factor Video Blog
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The art of TFF origami

The limitless design, exquisite accuracy and elegant simplicity of origami have been brought to TFF systems. Configure your optimal KTF KrosFlo® TFF system from the same starting point to satisfy your specific process needs. We have systems down to a science … and an art.

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The 3-Minute drill

If you have three minutes, then you have enough time to install a TFDF® flow path. Mount the device, make a few connections and you’re done - without ever breaking a sweat.

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The OPUS® time machine

OPUS® Columns pack your choice of resin and the most precious element of all, time, into a self-packed ready-to-use chromatography column at almost any size and for almost every application. Skip months of hardware validation, execute more runs--and still leave work early to enjoy a bike ride. Don’t worry, we won’t tell your boss.

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Think outside the blocks

Intensification is worth it. Build an intensified upstream suite brick by brick with XCell ATF® systems. Make twice as much product in half the time as you watch VCD grow and shrink bioreactor sizes within the same facility footprint.

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Espresso depth filtration

Replace sluggish messy depth filtration with combined tangential flow and depth filtration. No need to load multiple filters or hunt for parts. At 1L through 2000L, connect one fully integrated filter module and go -- at flux speeds up to 1950 LMH.

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Protein Concentration Determination and Automation During Drug Product Dilution Processes Using FlowVPE System

Protein concentration is one of the critical quality attributes of fill-finished drug products, as it ultimately defines the dosage a patient receives. Process analytical tools are key in monitoring this attribute and are used to control the manufacturing process accordingly. This presentation will give an overview of the journey from initial laboratory feasibility tests of the CTech FlowVPE technology to implementation into an aseptic GMP facility for in-process control testing of biologics. In addition, the talk will highlight how the inline technology sheds new light on the manufacturing process and increases product understanding. Building on the availability of real-time continuous protein concentration data, next steps in the development and implementation of a future automated human-free process execution will be shared.

Speaker: Raf De Dier, Associate Director Advanced Technology – Janssen.

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Resuspension

The off bottom lift promotes a quick and efficient resuspension of settled solids. 

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Bioprocessing Expert Panel Discussion Part 1 – PAT Implementation