You are using an unsupported browser.
Some features of this site may not function properly. For optimal user experience, please view this site in Chrome, Firefox, Safari, or Edge.

NGL COVID-19 Spike Protein Affinity Resin

Novel SARS CoV-2 specific affinity resin enables a high purity capture step, decreased process time, and yield improvement for the commercial production of COVID-19 vaccines.

Icon_NEW.jpg sars CoV-2 Specific affinity Resin

for the purification of COVID-19 vaccines

Novel affinity resin for the purification of the SARS CoV-2 Spike Protein for vaccine development and manufacturing

The result of close work with Navigo Proteins on the ligand development and partnership with Purolite Life Sciences on Praesto® agarose bead technology, the new NGL COVID-19 Spike Protein Affinity Resin from Repligen binds the SARS CoV-2 Spike Protein receptor binding domain (RBD) to yield exceptional purity in a single chromatography step. The product meets all the expected requirements of a high-performance resin, including very high selectivity, high dynamic binding capacities and caustic stability over multi-cycle use.

The resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid implementation as well as in loose resin formats.

Single-step affinity chromatography with high resolution

NGL COVID-19 Spike Protein Affinity Resin key features include:

  • Single-step purification of SARS-CoV-2 spike protein RBD containing modalities*
  • Compatible with 0.1N NaOH for CIP
  • High binding capacity **
* Targets SARs CoV-2 spike protein variants containing the RBD. Examples include: S protein (S1/S2), S1 Protein, RBD, S Protein Trimer. Development data suggest that purification of whole inactiviated virus, virus like particles (VLPs), and adenovirus may not yield satisfactory results.
**Actual DBC dependent on S protein variant & size

optimized bead chemistry delivers exceptional purity

NGL COVID-19 Spike Protein Affinity Resin delivers >90% purity in one chromatography step.

SDS-PAGE gel of the SARS-CoV-2 Spike protein Receptor Binding Domain (RBD) expressed in HEK293 cells and purified with NGL COVID-19 Spike Protein Affinity Resin.  

Available Pre-packed in OPUS® Columns for quick deployment

 

The NGL COVID-19 Spike Protein Affinity Resin is available in off-the shelf, pre-packed and pre-qualified OPUS® Columns for rapid GMP implementation as well as in loose resin formats.

OPUS® Columns allow you to progress from development to manufacturing scale in weeks, using pre-packed and pre-qualified chromatography columns.

About OPUS® Columns