Spectrum® Hollow Fiber Filter Modules

Hollow fiber filter modules for tangential flow filtration (TFF) from Repligen are industry standards in the filtration and concentration of biologics. Manufactured in compliance with ISO guidelines, the filters are used in thousands of Krosflo TFF Systems and XCell™ ATF Systems worldwide, as well as other industry hollow fiber TFF systems.

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Scale-up made easy

Hollow fiber filter TFF modules are offered with a broad range of sizes, surface areas and membrane chemistries designed to facilitate easy scale-up from small volume process development and R&D applications to commercial production. During scale-up, adding more fibers to process larger volumes enables consistency in the length of the filtration flow path even while the surface area of the filter is increased.

  Primary Application Volume Inlet/ Outlet Side Port Scale Length Effective Length (cm) Total Length (cm) Surface area

MicroKros

               

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Process characterization, Small-volume TFF in a laboratory 1-100 ml MLL FLL 1 x FL
2 x FL
3 x FL
20
41.5
65
25
45
69
13 – 20 cm2
26 - 59 cm2
41 - 92 cm2

MidiKros

               

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Process development at small scale 100 ml - 3 L FLL FLL 1 x FL
2 x FL
3 x FL
20
41.5
65
25
45
69
75 – 190 cm2
155 - 390 cm2
245 - 610 cm2

MidiKros TC

               

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Process development at pilot scale 100 ml - 3 L 1/2" TC FLL 1 x FL
2 x FL
3 x FL
20
41.5
65
25
45
69
75 – 190 cm2
155 - 390 cm2
245 - 610 cm2

MiniKros Sampler

               

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Batch TFF of small volumes 3 L -15 L 0.75" TC 0.75" TC 1 x FL
2 x FL
3 x FL
20
41.5
65
25
47
70
490 – 1000 cm2
1000 - 2200 cm2
1600 - 3400 cm2

MiniKros

               

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Pilot-scale TFF 5 L - 50 L 1.5" TC 0.75" TC 1 x FL
2 x FL
3 x FL
20
41.5
65
25
46
70
0.16 - 0.31 m2
0.32 - 0.65 m2
0.51 - 1.0 m2

KrosFlo®

               

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Production-scale TFF 10 – 100L 3" TC 1.5" TC 1 x FL
2 x FL
3 x FL
20
41.5
65
23
46
69
0.78 - 1.6 m2
1.65 - 3.25 m2
2.55 - 5.10 m2

KrosFlo® MAX

               
Request a Quote Production-scale TFF 100L – 1000+L 6" TC 1.5" TC R65
3 x FL
R85
49.9
67.9
107.5
73.5
91.5
131.1
4.30 - 10.40 m2
7.10 - 17.10 m2
11.30 - 11.35 m2

Find the right Hollow Fiber Filter for your application

Online Hollow Fiber Selection Tool

Product Number Key

To specify the hollow fiber filter specific to your application, follow the product number key below.

Manufacturing Centers of Excellence

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands,  Germany and Estonia.

Locations

Customer First.

Support is part of the Repligen DNA. Our goal is to provide exceptional customer experience, and to support the efficient and successful adoption and implementation of all Repligen products and services.

  • Field Application Support
  • Customer Service
  • Field Service Engineers

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Configurators

Find a Spectrum Hollow Fiber Filter

Search for Spectrum Hollow Fiber Filters by Module Family, Membrane Chemistry, MWCO, and other parameters.

Hollow Fiber Calculator

Easy-to-use online Hollow Fiber Filter tool for calculating critical process parameters like Flow Rate Per Fiber, Holdup Volume, Total Surface Area, and more.