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Spectrum® Hollow Fiber Filter Modules

Ideal for ultrafiltration, diafiltration and microfiltration, single-use hollow fiber filters for tangential flow filtration are packed in housings engineered to handle high pressures, with a choice of fiber chemistries and sizes from process development to manufacturing.

spectrum® Hollow Fiber Filter Modules

Hollow fiber filter modules for tangential flow filtration (TFF) from Repligen are industry standards in the filtration and concentration of biologics. Manufactured in compliance with ISO guidelines, the filters are used in thousands of Krosflo® TFF Systems and XCell™ ATF Systems worldwide, as well as other industry hollow fiber TFF systems.

How hollow fiber TFF works   

Scalable

From process development to commercial manufacturing

broad range

Selection of sizes, surface areas, 4 membrane chemistries

High yield

Fast processing, high flux rates, low protein binding

Quality manufacturing

Manufactured in compliance with ISO guidelines

Compatible

For use with standard industry hollow fiber TFF systems

 

Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.

about Repligen Manufacturing

Scale-up made easy

Hollow fiber filter TFF modules are offered with a broad range of sizes, surface areas and membrane chemistries designed to facilitate easy scale-up from small volume process development and R&D applications to commercial production. During scale-up, adding more fibers to process larger volumes enables consistency in the length of the filtration flow path even while the surface area of the filter is increased.

Hollow fiber membranes

  Primary
Application
Volume Inlet/ Outlet Side
Port
Scale
Length
Effective Length (cm) Total
Length (cm)
Surface
area

MicroKros

               

MicroKros.png

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Process characterization,
Small-volume TFF in a laboratory
1-100 ml MLL FLL 1 x FL
2 x FL
3 x FL
20
41.5
65
25
45
69
13 – 20 cm2
26 - 59 cm2
41 - 92 cm2

MidiKros

               

MidiKros.png

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Process development at small scale 100 ml - 3 L FLL FLL 1 x FL
2 x FL
3 x FL
20
41.5
65
25
45
69
75 – 190 cm2
155 - 390 cm2
245 - 610 cm2

MidiKros TC

               

MidiKros-TC.png

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Process development at pilot scale 100 ml - 3 L 1/2" TC FLL 1 x FL
2 x FL
3 x FL
20
41.5
65
25
45
69
75 – 190 cm2
155 - 390 cm2
245 - 610 cm2

MiniKros Sampler

               

MiniKros-Sampler.png

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Batch TFF of small volumes 3 L -15 L 0.75" TC 0.75" TC 1 x FL
2 x FL
3 x FL
20
41.5
65
25
47
70
490 – 1000 cm2
1000 - 2200 cm2
1600 - 3400 cm2

MiniKros

               

MiniKros.png

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Pilot-scale TFF 5 L - 50 L 1.5" TC 0.75" TC 1 x FL
2 x FL
3 x FL
20
41.5
65
25
46
70
0.16 - 0.31 m2
0.32 - 0.65 m2
0.51 - 1.0 m2

KrosFlo®

               

KrosFlo.png

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Production-scale TFF 10 – 100L 3" TC 1.5" TC 1 x FL
2 x FL
3 x FL
20
41.5
65
23
46
69
0.78 - 1.6 m2
1.65 - 3.25 m2
2.55 - 5.10 m2

KrosFlo® MAX

               

KrosFlo-MAX.png

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Production-scale TFF 100L – 1000+L 6" TC 1.5" TC R65
3 x FL
R85
49.9
67.9
107.5
73.5
91.5
131.1
4.30 - 10.40 m2
7.10 - 17.10 m2
11.30 - 11.35 m2

Product Number  Key

To specify the hollow fiber filter specific to your application, follow the product number key below.

 

HF product key.jpg