NEW | Designed and engineered as a complete solution, the XCell™ Lab System integrates devices, controller and software, enabling low volume process intensification ready for scale-up.
2x Device Capacity
1 controller supports up to 2 devices
1 manifold supports up to 8 devices
Elegant powerful interface
Software designed for technical control and easy navigation
User-definable HMI customizations
Fully integrated system
All components validated as a complete system
Easy connectivity to any bioreactor
Intensification ready
Consistent flow rates with increasing viscosity
Permeate pressure data for improved characterization
Integrated pressure sensors
Global Support
Field Applications and Service Specialists provide worldwide support
5th Generation Controller with Precision Engineering
The XCell™ Lab controller is engineered for robust intensification and user-friendly experience.
- Maintain precise flow rates even at high viscosities during the late stages of intensification development using a control logic loop with re-engineered hardware.
- Monitor real-time filter status using a recording of permeate pressure data .
- Configure alarms for key process events at just the right moment, reducing errors and maximizing efficiency.
- Visualize key trending data on a tablet-based graphical interface designed for clarity makes the system enjoyable to use.
- Increase productivity by deploying up to two filtration devices that can be configured on either one bioreactor or two.
XCell ATF® Lab Devices
XCell ATF® Devices are available in single-use and stainless-steel formats, with working volumes from 0.5 L to 50 L. The new XCell ATF® 1 Device supports the smallest working volume and features integrated accessories, including an AseptiQUIK® connector for sterile bioreactor connectivity and a permeate pressure sensor.
XCell ATF® 1 Device (SU)
0.5-2 L
XCell ATF® 2 Device (SU, SS)
2-10 L
XCell ATF® 4 Device (SS)
10-50 L
Consistent flow rates with increasing viscosity
Consistent flow rates with increasing viscosity help ensure robust development and manufacturing scale-up.
- Overlapping lines demonstrate that the correlation between volumetric flow rate and shear set point remains consistent with increasing viscosity.
- The consistent flow rate is maintained using a new valve and control logic loop that enables precision pumping.
Software designed for technical control
Modern minimalist layout
- Image adapts to actual equipment in use
- Fast familiarization through colors and format
- Alarms graphically associated with specific component
Graphics confirm text input
- Single button selection (iPhone-like)
- Integrated device pictures and part numbers
- Automatic shear calculations
Configurable set-up delivers high throughpuT
One XCell™ Lab Controller can support up to two XCell ATF® Devices that can be configured on either one or two bioreactors.
A single manifold can support up to 8 XCell ATF® Devices.
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An interface ready for your lab environment
- Splash-proof case protects against lab hazards and accidents
- Mountable arm adjusts position to your environment
- So simple, no keyboard required
REPLIGEN technical support ENSUres Success
The Repligen Field Application team with expertise in XCell ATF® technology provide support from consultation to implementation globally.
Consultation
- Theory
- Technology fit
- Experimental plan
Evaluation
- Demonstration
- Training
- Data analysis
Development
- Optimization
- Flow Path sizing
- System sizing
Implementation
- Scale-up
- Validation
- Long-term training plan
Resources
High Productivity Harvest: A Novel Approach to Fed-batch Process Intensification
Mitigation of Protein Retention in Perfusion Process and Effect of Filter Pore Size
Demonstration of XCell ATF® 2 and XCell ATF® 6 Single-use Performance
Mitigation of Protein Retention in High Density Perfusion Process
Tools for Intensification of Cell Culture Production and Continuous Downstream Processing
ATF Perfusion Technology: Improved Fed-Batch Throughput and Reduced Seed Train Expansion
Special Report on Continuous Bioprocessing: Upstream, Downstream, Ready for Prime Time?
WuXi Biologics Expands Perfusion Cell Culture Capabilities using ATF 10 System
Continuous Manufacturing: A Changing Processing Paradigm
Developing an upstream process for a monoclonal antibody including medium optimization
Frequently asked questions | perfusion