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Scalable UV Light Source Solutions
UV Light Source Solutions for Variable Pathlength Spectroscopy
From multiwavelength spectrophotometer to GMP-compatible single-wavelength solutions, our interchangeable light sources seamlessly integrate with the PATsmart™ FlowVPX® System to address your diverse research, process development, and manufacturing needs.
product features
Increase Process Understanding
During the process development stage to accelerate product-to-market
Strengthen Your Process Control
With high quality and highly reproducible results
Reduce Cycling Time
By eliminating delays associated with off-line testing (yield, throughput, resource utilization)
Minimize Risk
With continuous monitoring throughout the process
Flexible Light Source Options
We understand your unique research, process development, and manufacturing work requires tailored solutions. That's why we are pleased to offer two light source options for use with the PATsmart™ FlowVPX® System.
The FlowVPX System plays a crucial role in your process optimization and control. It provides real-time results with unprecedented speed, enabling you to gather a greater number of quality data points for higher accuracy compared to off-line methods. The choice of light source allows for further optimization and even stronger process control.
Our compact single-wavelength light source and multiwavelength spectrophotometer are designed to be compatible with the FlowVPX System and interchangeable with one another.
This flexibility allows you to scale your project and seamlessly transitions between the two as your proven applications progress towards commercialization. Rest assured that at every stage of your development, we have you covered.
Single Wavelength Light Source: Easy-to-Use GMP Solution
The PATsmart™ Beams™ single-wavelength LED light source is a reliable and efficient option for applications where a specific wavelength has already been established and proven effective. With a simplified design and user-friendly interface, this light is perfect for manufacturing biologics, where consistency and precision are crucial.
- Proven performance: Designed specifically for established applications at 260 nm or 280 nm, the single-wavelength light source ensures accurate and repeatable measurements that meet the highest industry standards.
- Easy integration: The compact size of our single-wavelength light source makes it easy to integrate the FlowVPX System into any manufacturing environment without sacrificing valuable space or user-friendliness.
- GMP-ready design: With an IP65 and CE rating, the FlowVPX System with Beams light source drives towards GMP readiness. The FlowVPX System is available with ViPER SecureVPT Software, specifically designed to support compliance with 21 CFR Part 11. Additionally, for USP/EP/JP compliance, we have mapped out the qualification parallels of the FlowVPX with Beams System to the industry standards in our technical note:PATsmart Beams System Qualification and Pharmacopeia Compliance
The PATsmart Beams LED light source is a single-beam instrument that delivers precise and concentrated light and is ideal for wavelength-specific applications. It comes in 260 nm, 272 nm, 280 nm, and 310 nm as single wavelengths.
Multiwavelength Spectrophotometer: Empowering Process Development
For applications that demand versatility and flexibility, the FlowVPX System connected with the Agilent Cary 60 UV-Vis spectrophotometer offers a wide range of capabilities. It is the perfect choice for process development, research laboratories, and industries exploring more efficient avenues for concentration determination in real time.
The Cary 60 UV-Vis spectrophotometer is a double-beam instrument with a powerful xenon lamp. It has a wavelength range of 190–1100 nm that can be scanned in under three seconds.
Here's why you should consider our multiwavelength spectrophotometer:
- Broad wavelength range: Our multiwavelength spectrophotometer allows you to analyze a wide range of wavelengths (190 nm to 1100 nm), empowering you to explore different applications and adapt to evolving research needs.
- Research-driven flexibility: The multiwavelength spectrophotometer gives you the freedom to customize experiments, optimize processes, and delve into new research areas, unlocking endless possibilities.
Complete Confidence Regardless of Your Choice
We recognize that your needs are unique.
Whether you require a compact, single-wavelength light source for proven applications or a multiwavelength spectrophotometer for process development, we have the solution that best suits you.
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Comparability was demonstrated between the FlowVPX System using the Beams light source and the FlowVPX System using the Cary 60 as its light source. Findings revealed that both systems yield highly consistent results when compared to the at-line PATsmart™ SoloVPE® System.
Here we demonstrate the real-time concentration readings achieved by FlowVPX with Beams, showcasing the similarity to data obtained using FlowVPX with Cary 60, and finally compared to the at-line SoloVPE System, spanning a broad concentration range from 6 mg/ml to nearly 160 mg/ml of a monoclonal antibody.
Our data showcases the VPT platform's consistent, accurate, and reproducible results, regardless of the light source or placement (in-line/at-line). The VPT platform is the ideal choice to fulfill all your UV-Vis spectroscopy requirements from development to manufacturing.
Explore Specifications, Applications, and Support
Operating System: Windows 10 compatible
Software Environment:
- Beams light source: ViPER® v1.2 or newer when using Beams light source
- Cary 60 light source: Agilent WinUV Software Suite v5.1.0.1019 or newer
Required Computer Hardware:
- Min Processor: Intel i5 (i7 preferred)
- Min Hard drive: 250 GB (SSD preferred)
- Min RAM: 8 GB (16 GB preferred)
Support Services
Enjoy the benefit of year-round technical support, scheduled maintenance, and more. We offer one- to three-year service contracts for your FlowVPX System. Schedule a visit from a Repligen analytical representative to qualify your FlowVPX System.
Application Services
Supplementary to our standard support options, application services provide you with increased access to our highly knowledgeable and experienced professionals. We offer implementation, method development, and educational guidance to maximize the benefits of your variable pathlength solutions and the Slope Spectroscopy® technique.
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