Turbocharging pDNA Production: CDMO Case Study in Optimization
Improvements in plasmid DNA manufacturing processes are a MUST to satisfy the rising demand driven by gene therapies. Watch this insightful case study where we delve into advancements in plasmid DNA production through optimizing Tangential Flow Filtration (TFF). Learn how Forge Biologics, in collaboration with Repligen, achieved a 300% reduction in processing time while enhancing RNA removal and maintaining high supercoiled DNA levels.
Discover the impact of molecular weight cutoff and shear rate on plasmid DNA purification and strategies for successful scale-up to larger manufacturing environments.
Uncover technologies and techniques designed to:
- Reduce processing time by ~300%
- Address suboptimal RNA and protein removal
- Streamline scale-up for large volume manufacturing
- Highlight the importance of advanced process controls
May 26, 2025
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