Chromatography system redesigned: Engineered for superior recovery, bioactivity and risk mitigation

Abstract The gene therapy era has brought with it a new set of chromatography yield and operational challenges. Over-molded tubing connections and near dead-leg free valve blocks reduce turbulence, preserving gradient integrity before the column and peak to peak resolution after the column. Quattroflow® pumps and flow path optimization can abate shear stress and increase bioactivity. For set-up, connect closed and sterile pre-assembled kits with 3 AseptiQuik® connections and install in less then 30 minutes with no tools and no wizard. A case study on the positive impact on process yield and output will be discussed.