Right-first-time custom affinity resin development with unparalleled ligand library diversity

Traditional approaches to custom affinity resin development often start with a small number of scaffolds, explore limited ligand sequence space and struggle to reach the optimal combination of product specifications. Repligen has resolved these shortcomings by starting the process with >50 multifarious scaffolds and generating unprecedented final ligand library diversity. High binding capacity, selectable pH requirements and caustic stability have been achieved on the first iteration at an unparalleled success rate. Technical features of the development platform, success rate statistics, example performance metrics and economic drivers will be discussed.