You are using an unsupported browser.
Some features of this site may not function properly. For optimal user experience, please view this site in Chrome, Firefox, Safari, or Edge.

XCell ATF® Devices and Controllers

XCell ATF® Systems simplify and fast-track upstream intensification by providing an integrated solution consisting of an XCell ATF® Device, XCell™ Controller, software, tubing, pressure sensors and accessories. The family of Systems supports diverse applications across development from 1 L to 5000 L.

Xcell ATF® Device Size selection guide

Presented are hollow fiber filter areas, XCell ATF® Pump volumes, and typical bioreactor working volumes paired with each XCell ATF® Device. Actual capacity and vessel size depend upon specific cell culture process conditions.



Device Effective filter 
surface area 
Approximate ATF volume exchanged
Suspension cultures volume
XCell ATF® 1 0.022 0.017 0.5 - 2
XCell ATF® 2 0.13 0.1 2 -  10
XCell ATF® 4 0.77 0.4 10 - 50
XCell ATF® 6 2.5 1.3 50 - 200
XCell ATF® 10 11.0 6.0 200 - 1000

Xcell ATF® Devices by Scale

Expand All

XCell ATF® Devices By Format

Expand All

Icon_NEW.jpgXCell ATF® 1 Single-use Device

XCell ATF® 2 Single-use Device

XCell ATF® 6 Single-use Device

XCell ATF® 10 Single-use Device

XCell ATF® Single-use Tubing Sets

XCell ATF® 6 Single-use Tubing Set

XCell ATF® 10 Single-use Tubing Set


Filter Wetting Procedure

XCell ATF® single-use devices are supplied dry. To ensure robust filter performance, it is important to wet the filter prior to use.  The XCell ATF® Tubing Set and the suggested wetting protocols are designed to:

  • Ensure efficient and complete filter wetting by minimizing the formation of air pockets during the wetting process
  • Enable pre-use filter integrity testing while maintaining sterility
  • Provide a means for evaluating the sterility of the XCell ATF® device prior to establishing the bioreactor connection
  • Allow change-out of the XCell ATF® device during a cell culture run without interrupting the bioreactor or XCell ATF® operation

Two wetting procedures have been developed: an off-line procedure and an on-line procedure.  After filter wetting, a filter integrity test can be performed. Additional detail can be obtained in the XCell ATF® Single-use User Guides.

Watch the video to see the XCell ATF® offline wetting procedure.

XCell ATF® 2 Stainless Steel Device

XCell ATF® 4 Stainless Steel Device

XCell ATF® 6 Stainless Steel Device

XCell ATF® 10 Stainless Steel Device

How to Install a Hollow Fiber Filter

Watch the video on how to install a hollow fiber filter into an XCell ATF® 10 stainless steel device.

Expand All

Icon_NEW.jpgXCell™ Lab Controller

   for use with:

XCell ATF® 1 (SU)
XCell ATF® 2 (SU,SS)
XCell® ATF 4 (SS)

XCell ATF® C410 Controller

for use with:

XCell ATF® 4 (SS)
XCell ATF® 6 (SU, SS)
XCell ATF® 10 (SU, SS)

XCell ATF® C410 Controller Cart


Expand All